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Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae)

Received: 29 January 2020     Accepted: 19 February 2020     Published: 28 February 2020
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Abstract

The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.

Published in American Journal of BioScience (Volume 8, Issue 1)
DOI 10.11648/j.ajbio.20200801.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Securidaca longepedunculata, Flavonoids, Phenolic Acids, β-hematin, Antiplasmodial

References
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    Issa Karama, Moussa Compaoré, Abdoulaye Djandé, Orokia Traoré, Latifou Lagnika, et al. (2020). Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). American Journal of BioScience, 8(1), 1-5. https://doi.org/10.11648/j.ajbio.20200801.11

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    ACS Style

    Issa Karama; Moussa Compaoré; Abdoulaye Djandé; Orokia Traoré; Latifou Lagnika, et al. Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). Am. J. BioScience 2020, 8(1), 1-5. doi: 10.11648/j.ajbio.20200801.11

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    AMA Style

    Issa Karama, Moussa Compaoré, Abdoulaye Djandé, Orokia Traoré, Latifou Lagnika, et al. Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). Am J BioScience. 2020;8(1):1-5. doi: 10.11648/j.ajbio.20200801.11

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  • @article{10.11648/j.ajbio.20200801.11,
      author = {Issa Karama and Moussa Compaoré and Abdoulaye Djandé and Orokia Traoré and Latifou Lagnika and Martin Kiendrebeogo},
      title = {Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae)},
      journal = {American Journal of BioScience},
      volume = {8},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.ajbio.20200801.11},
      url = {https://doi.org/10.11648/j.ajbio.20200801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20200801.11},
      abstract = {The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae)
    AU  - Issa Karama
    AU  - Moussa Compaoré
    AU  - Abdoulaye Djandé
    AU  - Orokia Traoré
    AU  - Latifou Lagnika
    AU  - Martin Kiendrebeogo
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    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajbio.20200801.11
    DO  - 10.11648/j.ajbio.20200801.11
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
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    EP  - 5
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20200801.11
    AB  - The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.
    VL  - 8
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Author Information
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

  • Department of Chemistry, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

  • Department of Biochemistry and Cell Biology, University of Abomey-calavi, Cotonou, Benin

  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

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